Impact of novel risk factors of atherosclerosis on severity of coronary artery disease in young Indian patients suffering from Myocardial Infarction

Abstract Funding Acknowledgements Type of funding sources: None. Background Asian Indians are affected at least a decade earlier with cardiovascular diseases (CVD), in their most productive midlife years as compared to people European ancestry. This is the first study from Indian sub-continent assessing impact novel risk factors atherosclerosis on angiographic severity coronary artery disease (CAD) terms SYNTAX scores young patients (<40 years) suffering myocardial infarction (MI). Purpose was undertaken evaluate association CAD index hospitalization MI patients. Methods In this single center observational study, 75 consecutive were included. Patients having previous CVD, chronic kidney disease, Liver and any bleeding diathesis excluded. Homocysteine, highly sensitive C- reactive protein (hs-CRP) lipoprotein- (Lp-a) measured correlated I II. Results Smoking (85.5%) common traditional factor for while other did not have significant effect MI. The mean homocysteine level 24.43± 10.02 micromole/L, hs-CRP 8.2± 1.44 mg/L Lp(a) 59± 23.10 mg/dL. sensitivity specificity ³8.5 prediction multivessel 67% 70% respectively that ³ 66.5 mg/dL 71% respectively. On further analysis, value score > 22 75% 65% 60% multivariate linear regression, predictor (p=0.03) when adjusted Lp (a). Conclusions levels significantly associated should be evaluated along routine early detection, timely management prevention major cardiac events.